Inbreeding Coefficient

Level of inbreeding for an individual A is defined as the probability that both alleles in one locus are derived from the same gene in an ancestor. Two alleles derived from the same gene in an ancestor are said to be identical by descent. This probability F(A) is called the "inbreeding coefficient" (From Wikipedia).

Inbreeding coefficient can be calculated with pedigree information and genomic information-based approaches. WISARD can calculate inbreeding coefficient by using --inbreed option.

To obtain the stable estimates for inbreeding coefficient, several things must be considered:

• Large number of samples and common variants to obtain accurate results.
• The in silico estimates of inbreeding are biased downward by the ascertainment bias due to being under-representative of the whole population or genealogies.

Consider the example code:

Output file [top]

Running the above command produces the output file, inbreed.coef.res. The meaning of each column in output file is: