What is PHARAOH-GEE?

Pathway-based approach using HierArchical structure of collapsed RAre variants OHigh-throughput sequencing data using Generalized Estimating Equations (PHARAOH-GEE) is a novel statistical approach for multivariate analysis of rare variants using Generalized Estimating Equations (GEE).

PHARAOH-GEE is possible to investigate an association between clustered phenotypes and each pathway or entire pathways simultaneously, regarding the relatedness across entire pathways, using collapsed rare variants using gene information.

PHARAOH-GEE implemented doubly ridge method for an analysis of entire pathways.

News

March 1, 2018 : PHARAOH-GEE website opened.

Contact

The PHARAOH program has developed by Sungyoung Lee (biznok@gmail.com)
(currently Center for Precision Medicine, Seoul National University Hospital, Korea.,
previously Interdisciplinary Program in Bioinformatics, Seoul National University, Korea.)