A novel fuzzy set based multifactor dimensionality reduction method for detecting gene-gene interaction (EFMDR)
This method is an extension of Fuzzy MDR without tuning parameters. Details of Fuzzy MDR is explained in the following paper. In this EFMDR method, the membership degree is estimated by the maximum likelihood estimator of the proportion of cases(controls) in each genotype combination. More details of EFMDR will be updated as soon as published.
Jung, H.-Y., et al. (2016) A novel fuzzy set based multifactor dimensionality reduction method for detecting gene-gene interaction, Computational Biology and Chemistry.
# an example of 2-locus analysis using MDR sample data library(MDR) data("mdr1") res<-EFMDR(mdr1,2) plot_EFMDR(res,2)
The above R code be download from the below link.